CareLit · DOI-Nachweis · Klinische Pädiatrie
Identification of common and distinct epigenetic re-programming properties of Core-Binding Factor (CBF) Fusion Proteins
DOI 10.1055/s-0036-1582520
Bibliografische Angaben
Nachweis in CareLit
Autor:innenJ Loke, A Ptasinska, MR Imperato, SA Assi, P Cauchy, I Cowell, O Heidenreich, M Raghavan, R Delwel, PN Cockerill, C Bonifer
ZeitschriftKlinische Pädiatrie
Ausgabe05/2016
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: Leukaemia can be caused by translocations involving the transcription factor RUNX1 which results in the formation of CBF fusion proteins. The most common is RUNX1-ETO; a second is RUNX1-EVI1. Methods: We performed DNaseI-seq and RNA-seq in patients with CBF leukaemia. We used ChIP-seq to identify RUNX1 and CBF fusion protein binding sites. To identify which genes are directly responsive to RUNX1-EVI1,…
Zitieren
Zitierempfehlung
J Loke, A Ptasinska, MR Imperato, SA Assi, P Cauchy, I Cowell, O Heidenreich, M Raghavan, R Delwel, PN Cockerill, C Bonifer (2016) Identification of common and distinct epigenetic re-programming properties of Core-Binding Factor (CBF) Fusion Proteins. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0036-1582520
Mit CareLit weiterarbeiten