CareLit · DOI-Nachweis · Klinische Pädiatrie
A Whole Genome In Vivo CRISPR Screen in Primary ALL Predicts the Relapse
DOI 10.1055/s-0036-1582521
Bibliografische Angaben
Nachweis in CareLit
Autor:innenK Dormon, E Latif, D Pal, M Bashton, M Selby, H Blair, V Rand, A Hall, J Vormoor, O Heidenreich
ZeitschriftKlinische Pädiatrie
Ausgabe05/2016
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: Investigating gain of drug resistance in ALL is complicated by questions about a suitable model, cell lines are by and large not drug naïve and patient material does not grow well in vitro. To this end we have sought to show that CRISR Cas9 genome editing technology can be used in patient derived ALL material in vivo to study emergence of drug resistance. Methods: We used primografted material from pat…
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Zitierempfehlung
K Dormon, E Latif, D Pal, M Bashton, M Selby, H Blair, V Rand, A Hall, J Vormoor, O Heidenreich (2016) A Whole Genome In Vivo CRISPR Screen in Primary ALL Predicts the Relapse. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0036-1582521
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