CareLit · DOI-Nachweis · Klinische Pädiatrie
Deciphering the oncogenic network of PRC-2 loss guided leukemogenesis
DOI 10.1055/s-0036-1582524
Bibliografische Angaben
Nachweis in CareLit
Autor:innenD Schneider, JH Klusmann, D Heckl
ZeitschriftKlinische Pädiatrie
Ausgabe05/2016
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: Mutations in EZH2 (including -7/-7q) and other PRC2 subunits have been described in adults with AML and MDS, in children with Down syndrome AML or JMML. Since myeloid neoplasms are elicited by accumulation of cooperating mutations, we aimed to decipher oncogenic cooperation with loss of PRC2-activity. Results: To this end, CRISPR-Cas9 screenings with oncogene/tumor suppressor pools (a total of 15 candi…
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Zitierempfehlung
D Schneider, JH Klusmann, D Heckl (2016) Deciphering the oncogenic network of PRC-2 loss guided leukemogenesis. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0036-1582524
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