CareLit · DOI-Nachweis · Klinische Pädiatrie
Deciphering the deregulated, complex transcription network in Down syndrome myeloid leukemia
DOI 10.1055/s-0036-1582525
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Autor:innenS Gialesaki, L Stachorski, JH Klusmann
ZeitschriftKlinische Pädiatrie
Ausgabe05/2016
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: Children with Down syndrome (DS) have a high risk to develop myeloid leukemia (ML-DS) and antecedent transient abnormal myelopoiesis (TAM). Mutations in exon 2 of GATA1 (GATA1 s-mutations) are necessary and sufficient to induce TAM in synergy with trisomy 21. In contrast, Gata1 Δe2 (Gata1 s) mice crossed with Ts65dn mice, which are trisomic for ˜60% of the genes orthologous to human chromosome 21, do n…
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Zitierempfehlung
S Gialesaki, L Stachorski, JH Klusmann (2016) Deciphering the deregulated, complex transcription network in Down syndrome myeloid leukemia. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0036-1582525
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