CareLit · DOI-Nachweis · Klinische Pädiatrie
Targeting pediatric acute lymphoblastic leukemia with oncolytic measles
DOI 10.1055/s-0036-1582526
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Autor:innenAV Goß, C Dorneburg, KM Debatin, C Beltinger
ZeitschriftKlinische Pädiatrie
Ausgabe05/2016
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background: Children with relapsed acute lymphoblastic leukemia (ALL) have a poor prognosis. Oncolytic viruses, i.e. attenuated measles (OMV), are effective against solid tumors. It was unknown whether OMV is efficacious in pediatric ALL. Methods: OMV leukemolysis of pediatric primary B lineage ALL cells and xenografts (PDXs) was analysed by flow cytometry. OMV replication was examined as cytotoxic effect on indicat…
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Zitierempfehlung
AV Goß, C Dorneburg, KM Debatin, C Beltinger (2016) Targeting pediatric acute lymphoblastic leukemia with oncolytic measles. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0036-1582526
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