CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
The non-steroidal FXR agonists PX20606 and GS-9674 improve liver fibrosis and portal hypertension in rodent models of cholestatic, metabolic and toxic liver cirrhosis
DOI 10.1055/s-0036-1583977
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Autor:innenT Reiberger, P Schwabl, P Supper, D Bauer, BA Payer, N Rohr-Udilova, B Podesser, C Kremoser, M Trauner
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe05/2016
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
Background: FXR agonists show beneficial effects in cholestasis and NASH. We evaluated the non-steroidal FXR agonists PX20606 and GS-9674 in rodent models of toxic (CCl4), and metabolic (NASH) liver fibrosis. Methods: Toxic model: CCl4 2x/week i.p. for 12weeks. PX20606 (10 mg/kg/day) was given from weeks4 – 12 of CCl4. NASH model: choline-deficient high-fat diet plus repeated NaNO2 (25 mg/kg i.p., 2x/week) for 10 we…
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Zitierempfehlung
T Reiberger, P Schwabl, P Supper, D Bauer, BA Payer, N Rohr-Udilova, B Podesser, C Kremoser, M Trauner (2016) The non-steroidal FXR agonists PX20606 and GS-9674 improve liver fibrosis and portal hypertension in rodent models of cholestatic, metabolic and toxic liver cirrhosis. Zeitschrift für Gastroenterologie (05). https://doi.org/10.1055/s-0036-1583977
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