CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
A novel PAK1/Notch-1 axis contributes to intestinal inflammation and cancer
DOI 10.1055/s-0036-1583981
Bibliografische Angaben
Nachweis in CareLit
Autor:innenA Frick, V Khare, K Dammann, C Gasche
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe05/2016
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background: PAK1 belongs to a family of serine-threonine kinase and contributes to various oncogenic pathways like MAPK and Wnt-β catenin. Our lab recently linked activation of p21-activated kinase (PAK1) to IBD as well as colitis-associated cancer (Khare V, Inflamm Bowel Dis 2015). Here we tested the effects of PAK1 deletion on intestinal inflammation and carcinogenesis in IL-10 KO mice. Methods: IL-10 KO mice were…
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Zitierempfehlung
A Frick, V Khare, K Dammann, C Gasche (2016) A novel PAK1/Notch-1 axis contributes to intestinal inflammation and cancer. Zeitschrift für Gastroenterologie (05). https://doi.org/10.1055/s-0036-1583981
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