CareLit · DOI-Nachweis · Diabetologie und Stoffwechsel
Repin1 deficiency improves insulin sensitivity and glucose metabolism in db/db mice by reducing adipose tissue mass and inflammation
DOI 10.1055/s-0036-1584107
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Autor:innenN Hesselbarth, A Kunath, M Gericke, M Kern, S Dommel, P Kovacs, M Stumvoll, M Blüher, N Klöting
ZeitschriftDiabetologie und Stoffwechsel
Ausgabe06/2016
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
Replication initiator 1 (Repin1) is a zinc finger protein playing a role in insulin sensitivity, body fat mass and lipid metabolism by regulating the expression key genes of glucose and lipid metabolism. Here, we tested the hypothesis that introgression of a Repin1 deletion into db/db mice improves glucose metabolism in vivo. We generated a whole body Repin1 deficient db/db double knockout mouse (Rep1-/-x db/db) and…
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Zitierempfehlung
N Hesselbarth, A Kunath, M Gericke, M Kern, S Dommel, P Kovacs, M Stumvoll, M Blüher, N Klöting (2016) Repin1 deficiency improves insulin sensitivity and glucose metabolism in db/db mice by reducing adipose tissue mass and inflammation. Diabetologie und Stoffwechsel (06). https://doi.org/10.1055/s-0036-1584107
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