CareLit · DOI-Nachweis · Pneumologie
The effect of the antiinflammatory IL-1R antagonist anakinra in mice with CF-like lung disease and Pseudomonas aeruginosa infection
DOI 10.1055/s-0036-1584630
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Nachweis in CareLit
Autor:innenA Schütte, Z Zhou-Suckow, J Schatterny, S Schmidt, S Hassel, M Weitnauer, A Dalpke, M Mall
ZeitschriftPneumologie
Ausgabe07/2016
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
Introduction: Spontaneous neutrophilic inflammation can be triggered by hypoxic epithelial necrosis in mucus-obstructed airways via the release of IL-1a in Scnn1b-Tg mice with CF-like lung disease, as recently reported. In this model, the inhibition of the IL-1R-MyD88 pathway with the IL1-R antagonist anakinra reduced airway neutrophilia and structural lung damage (Fritzsching B. et al., AJRCCM 2015). However, effec…
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Zitierempfehlung
A Schütte, Z Zhou-Suckow, J Schatterny, S Schmidt, S Hassel, M Weitnauer, A Dalpke, M Mall (2016) The effect of the antiinflammatory IL-1R antagonist anakinra in mice with CF-like lung disease and Pseudomonas aeruginosa infection. Pneumologie (07). https://doi.org/10.1055/s-0036-1584630
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