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Stem cell transplantation in a cystic fibrosis mouse model induced Cftr genotype conversion and improved outcome of P. aeruginosa lung infection

A Munder, S Hedtfeld, C Happle, N Lachmann, R Gastmeier, A Schambach, G Hansen, B Tümmler · Pneumologie · Ausgabe 07/2016

DOI 10.1055/s-0036-1584631

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Autor:innenA Munder, S Hedtfeld, C Happle, N Lachmann, R Gastmeier, A Schambach, G Hansen, B Tümmler
ZeitschriftPneumologie
Ausgabe07/2016
Jahrgang / SeitenNicht angegeben

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Abstract-Vorschau

Infections with Pseudomonas aeruginosa still cause severe morbidity in people with Cystic fibrosis (CF). The Gram-negative, opportunistic pathogen is nearly perfectly adapted to the microaerophilic conditions within the CF lung characterized by impaired ciliary function, mucus plugging and progressive remodeling. This scenario of chronic inflammation and loss of lung function is not only caused by the loss of functi…

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A Munder, S Hedtfeld, C Happle, N Lachmann, R Gastmeier, A Schambach, G Hansen, B Tümmler (2016) Stem cell transplantation in a cystic fibrosis mouse model induced Cftr genotype conversion and improved outcome of P. aeruginosa lung infection. Pneumologie (07). https://doi.org/10.1055/s-0036-1584631

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