CareLit · DOI-Nachweis · Pneumologie
Investigating the role of cathepsin S in the pathogenesis of cystic fibrosis-like lung disease
DOI 10.1055/s-0036-1584637
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Nachweis in CareLit
Autor:innenRR Brown, DM Small, AA Abladey, LJ Holsinger, R Booth, CJ Scott, JS Elborn, MA Mall, S Weldon, CC Taggart
ZeitschriftPneumologie
Ausgabe07/2016
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: Elevated levels of the cysteine protease cathepsin S (cat S) are found in Cystic fibrosis (CF) lung secretions, however, the role of cat S in CF lung disease is unclear. Cat S is capable of maintaining its activity at a neutral pH allowing it to remain active outside of the cell. Consequently, cat S has the capacity to promote remodelling of the extracellular matrix via its potent elastolytic activity.…
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Zitierempfehlung
RR Brown, DM Small, AA Abladey, LJ Holsinger, R Booth, CJ Scott, JS Elborn, MA Mall, S Weldon, CC Taggart (2016) Investigating the role of cathepsin S in the pathogenesis of cystic fibrosis-like lung disease. Pneumologie (07). https://doi.org/10.1055/s-0036-1584637
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