CareLit · DOI-Nachweis · Pneumologie
Mass spectrometric analysis of ΔF508 CFTR interactome identifies new drug targets for Cystic Fibrosis
DOI 10.1055/s-0036-1584652
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Autor:innenC Bamberger, S Pankow, JR Yates
ZeitschriftPneumologie
Ausgabe07/2016
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Cystic fibrosis (CF) is one of the most common genetic childhood diseases, affecting 1:2500 newborns in Europe. The disease is caused by loss-of-function mutations in the anion channel Cystic Fibrosis Transmembrane Conductance Regulator (CFTR). Deletion of F508 in CFTR (ΔF508 CFTR) is the most prevalent mutation, occurring in more than 70% of CF patients. Children with CF suffer from unusually thick mucus in the lun…
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Zitierempfehlung
C Bamberger, S Pankow, JR Yates (2016) Mass spectrometric analysis of ΔF508 CFTR interactome identifies new drug targets for Cystic Fibrosis. Pneumologie (07). https://doi.org/10.1055/s-0036-1584652
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