CareLit · DOI-Nachweis · Pneumologie
A soluble factor mediates alpha-1 antitrypsin-induced inhibition of ATP-induced IL-1β release by monocytic cells
DOI 10.1055/s-0036-1584659
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Autor:innenR Siebers, B Fink, K Richter, S Wilker, M Küllmar, S Zukunft, N Aggarwal, A Zakrzewicz, W Padberg, S Janciauskiene, V Grau
ZeitschriftPneumologie
Ausgabe07/2016
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: Alpha-1 antitrypsin (AAT), a major antiprotease of the lung, exerts anti-inflammatory functions via poorly defined pathways. At previous DZL meetings, we provided evidence that AAT is a potent inhibitor of ATP-induced release of IL-1β from human monocytes, and that CD36, calcium-independent phospholipase A2 (iPLA2) and nicotinic acetylcholine receptor (nAChR) subunit α9 participate in this mechanism. H…
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Zitierempfehlung
R Siebers, B Fink, K Richter, S Wilker, M Küllmar, S Zukunft, N Aggarwal, A Zakrzewicz, W Padberg, S Janciauskiene, V Grau (2016) A soluble factor mediates alpha-1 antitrypsin-induced inhibition of ATP-induced IL-1β release by monocytic cells. Pneumologie (07). https://doi.org/10.1055/s-0036-1584659
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