Genetic Determinants of Inflammation in Sarcoidosis

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Sarcoidosis is a multi-systemic granulomatous disorder of unknown aetiology. Most of the known or suspected genes involved in sarcoidosis play a role in an inflammatory response to an antigenic challenge, with predisposing genes mainly involved in T cell and macrophage function and antigen presentation and recognition. New data will be presented using common variant polygenic risk scores that demonstrates the underl…

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