CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Gemcitabine uptake and metabolism of cancer associated fibroblasts in murine pancreatic cancer
DOI 10.1055/s-0036-1587242
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Autor:innenM Patzak, E Hessmann, T Bapiro, K Frese, D Jodrell, V Ellenrieder, A Neesse
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe08/2016
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background and Aim: Desmoplasia and hypovascularity were shown to impede drug delivery in pancreatic ductal adenocarcinoma (PDAC). Here, we aim to dissect the differential gemcitabine uptake and metabolism in murine cancer cells and fibroblasts. Design: We analysed gemcitabine metabolites in primary murine tumour cells, cancer associated fibroblasts (CAFs) and pancreatic stellate cells (PSCs) by LC-MS/MS using a val…
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Zitierempfehlung
M Patzak, E Hessmann, T Bapiro, K Frese, D Jodrell, V Ellenrieder, A Neesse (2016) Gemcitabine uptake and metabolism of cancer associated fibroblasts in murine pancreatic cancer. Zeitschrift für Gastroenterologie (08). https://doi.org/10.1055/s-0036-1587242
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