Lost in translation? Therapeutic contrasts in CF and non-CF bronchiectasis

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Non-cystic fibrosis bronchiectasis is a significant cause of morbidity and mortality and its prevalence is increasing. Unlike CF, non-cystic fibrosis bronchiectasis (NCFB) is a heterogeneous disease, with a variety of predisposing factors and disease mechanisms implicated in its pathogenesis. However, the “vicious cycle” hypothesis is the generally accepted explanation for the evolution of bronchiectasis, both in CF…

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