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Plasmapheresis as rescue therapy in severe bronchiectasis with blocking anti pseudomonas antibodies

A De Soyza, TJ Wells, J Davison, E Sheehan, S Kanagasundaram, G Spickett, G Davies, CA MacLennan, R Stockley, I Henderson · Pneumologie · Ausgabe 10/2016

DOI 10.1055/s-0036-1592256

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Autor:innenA De Soyza, TJ Wells, J Davison, E Sheehan, S Kanagasundaram, G Spickett, G Davies, CA MacLennan, R Stockley, I Henderson
ZeitschriftPneumologie
Ausgabe10/2016
Jahrgang / SeitenNicht angegeben

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Abstract-Vorschau

Rationale: There are few salvage therapies for advanced bronchiectasis. Recently, we identified a subset of patients with non-cystic fibrosis bronchiectasis and chronic Pseudomonas aeruginosa infection (1). These patients had an excess of IgG2 specific to the bacterial O-antigen. This IgG2 inhibited immune killing of the infecting strain. Patients with inhibitory antibody had worse lung disease (1). Here we describe…

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A De Soyza, TJ Wells, J Davison, E Sheehan, S Kanagasundaram, G Spickett, G Davies, CA MacLennan, R Stockley, I Henderson (2016) Plasmapheresis as rescue therapy in severe bronchiectasis with blocking anti pseudomonas antibodies. Pneumologie (10). https://doi.org/10.1055/s-0036-1592256

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