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A Novel Combination of Tobramycin with a Potentiator for the Treatment of Chronic Pseudomonas aeruginosa Infections

M Koeva, A Gutu, F Ausubel, D Joseph-McCarthy · Pneumologie · Ausgabe 10/2016

DOI 10.1055/s-0036-1592276

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Autor:innenM Koeva, A Gutu, F Ausubel, D Joseph-McCarthy
ZeitschriftPneumologie
Ausgabe10/2016
Jahrgang / SeitenNicht angegeben

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Abstract-Vorschau

EBX-001, a combination of tobramycin with a bacterial metabolite as a potentiator, is being developed for the treatment of chronic P. aeruginosa infections in Cystic Fibrosis, non-CF bronchiectasis, and COPD patients. The combination utilizes an anti-persisters strategy and is aimed at reducing recurrent infections. P. aeruginosa cultures in planktonic stationary phase (PSP) were used to select for bacterial persist…

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M Koeva, A Gutu, F Ausubel, D Joseph-McCarthy (2016) A Novel Combination of Tobramycin with a Potentiator for the Treatment of Chronic Pseudomonas aeruginosa Infections. Pneumologie (10). https://doi.org/10.1055/s-0036-1592276

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