CareLit · DOI-Nachweis · Geburtshilfe und Frauenheilkunde
Neolacto glycosphingolipids promote Doxorubicin, Epirubicin, and organoarsenic PENAO sensitivity and hypoxia-induced HIF-1a accumulation in ovarian cancer cells
DOI 10.1055/s-0036-1592696
Bibliografische Angaben
Nachweis in CareLit
Autor:innenA Fedier, S Alam, K Winkelbach, R Kohler, V Heinzelmann-Schwarz, F Jacob
ZeitschriftGeburtshilfe und Frauenheilkunde
Ausgabe10/2016
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction/Aim: We investigate the yet unknown function of neolacto-glycosphingolipids GSLs (P1 and nLc4) on drug sensitivity and response to hypoxia, two major obstacles in cancer management. We used parental IGROV1 ovarian cancer cells and our previously generated knockout subline disrupted in B3GNT5 gene (B3GNT5-ko). B3GNT5 is the key enzyme in P1 and nLc4 biosynthesis. GSLs are located on the cell membranes an…
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Zitierempfehlung
A Fedier, S Alam, K Winkelbach, R Kohler, V Heinzelmann-Schwarz, F Jacob (2016) Neolacto glycosphingolipids promote Doxorubicin, Epirubicin, and organoarsenic PENAO sensitivity and hypoxia-induced HIF-1a accumulation in ovarian cancer cells. Geburtshilfe und Frauenheilkunde (10). https://doi.org/10.1055/s-0036-1592696
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