CareLit · DOI-Nachweis · Geburtshilfe und Frauenheilkunde
Novel drug OTSSP167 inhibits proliferation and induces apoptosis selectively in high-grade serous ovarian cancer cells
DOI 10.1055/s-0036-1592710
Bibliografische Angaben
Nachweis in CareLit
Autor:innenR Kohler, H Kettelhack, A Schötzau, A Fedier, F Jacob, H Heinzelmann-Schwarz
ZeitschriftGeburtshilfe und Frauenheilkunde
Ausgabe10/2016
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: Our previous transcriptomic analysis identified MELK (maternal embryonic leucine-zipper kinase), suggested to play a key role in carcinogenesis, to be overexpressed in epithelial ovarian cancer. MELK is elevated and correlates with poor prognosis also in basal-like breast cancer and its inhibition by OTSSP167 induced apoptosis in these cells. We analyzed MELK expression in high-grade serous ovarian can…
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Zitierempfehlung
R Kohler, H Kettelhack, A Schötzau, A Fedier, F Jacob, H Heinzelmann-Schwarz (2016) Novel drug OTSSP167 inhibits proliferation and induces apoptosis selectively in high-grade serous ovarian cancer cells. Geburtshilfe und Frauenheilkunde (10). https://doi.org/10.1055/s-0036-1592710
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