CareLit · DOI-Nachweis · Geburtshilfe und Frauenheilkunde
EZH2 is overexpressed in breast tumors with a BRCA1-like DNA copy number profile
DOI 10.1055/s-0036-1592820
Bibliografische Angaben
Nachweis in CareLit
Autor:innenJ Puppe, M Opdam, K Jozwiak, PC Schouten, S Rodenhuis, M Hauptmann, E Hahnen, P Mallmann, R Schmutzler, S Linn, J Jonkers
ZeitschriftGeburtshilfe und Frauenheilkunde
Ausgabe10/2016
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Purpose: The polycomb group protein EZH2 is an epigenetic repressor and overexpression of EZH2 is associated with highly aggressive types of breast cancer. Human BRCA1-mutated breast tumors carry a specific DNA copy-number signature (“BRCA1-like”) which is also found in tumors with a loss of BRCA1 function by other mechanism such as BRCA1-promoter methylation. Here, we explored whether EZH2 is overexpressed in human…
Zitieren
Zitierempfehlung
J Puppe, M Opdam, K Jozwiak, PC Schouten, S Rodenhuis, M Hauptmann, E Hahnen, P Mallmann, R Schmutzler, S Linn, J Jonkers (2016) EZH2 is overexpressed in breast tumors with a BRCA1-like DNA copy number profile. Geburtshilfe und Frauenheilkunde (10). https://doi.org/10.1055/s-0036-1592820
Mit CareLit weiterarbeiten