CareLit · DOI-Nachweis · Geburtshilfe und Frauenheilkunde
Dasatinib treatment results in a markedly diminished frequency of bone metastases after intracardiac injection of osteotropic MDA-MB-231 breast cancer cells in a xenograft mouse model
DOI 10.1055/s-0036-1593292
Bibliografische Angaben
Nachweis in CareLit
Autor:innenT Heilmann, M Roscher, AL Rumpf, M Gerle, M Tietgen, O Will, T Damm, N Maass, CC Glüer, S Tiwari, A Trauzold, C Schem
ZeitschriftGeburtshilfe und Frauenheilkunde
Ausgabe10/2016
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Aims: The development of skeletal breast cancer metastases depends on tumor cell Src-kinase activity. We were recently able to show that knockdown of TRAIL (TNF related apoptosis inducing ligand)-R2 in an osteotropic clone of MDA-MB-231 cells results in a diminished frequency of bone metastases by an impairment of homing mechanisms after intracardiac injection in a xenograft-mouse model. In vitro we also found a dow…
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Zitierempfehlung
T Heilmann, M Roscher, AL Rumpf, M Gerle, M Tietgen, O Will, T Damm, N Maass, CC Glüer, S Tiwari, A Trauzold, C Schem (2016) Dasatinib treatment results in a markedly diminished frequency of bone metastases after intracardiac injection of osteotropic MDA-MB-231 breast cancer cells in a xenograft mouse model. Geburtshilfe und Frauenheilkunde (10). https://doi.org/10.1055/s-0036-1593292
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