CareLit · DOI-Nachweis · Klinische Pädiatrie
The β-catenin/CBP-antagonist ICG-001 inhibits pediatric glioma tumorigenicity in a Wnt-independent manner
DOI 10.1055/s-0036-1593548
Bibliografische Angaben
Nachweis in CareLit
Autor:innenM Wiese, N Walther, C Diederichs, F Schill, S Monecke, B Downie, D Sturm, SM Pfister, R Dressel, SA Johnsen, CM Kramm
ZeitschriftKlinische Pädiatrie
Ausgabe11/2016
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Pediatric high-grade gliomas (pedHGG) belong to the most aggressive cancers in children with poor prognosis due to a lack of efficient therapeutic strategies. To identify therapeutic targets, intensive research in adult high-grade gliomas identified dysregulated and tumor-driving signal-transduction pathways. The β-catenin/Wnt-signaling pathway holds promising potential as treatment option in adults to abrogate tumo…
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Zitierempfehlung
M Wiese, N Walther, C Diederichs, F Schill, S Monecke, B Downie, D Sturm, SM Pfister, R Dressel, SA Johnsen, CM Kramm (2016) The β-catenin/CBP-antagonist ICG-001 inhibits pediatric glioma tumorigenicity in a Wnt-independent manner. Klinische Pädiatrie (11). https://doi.org/10.1055/s-0036-1593548
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