CareLit · DOI-Nachweis · Klinische Pädiatrie
Three-dimensional tumor cell growth models in vivo drug resistance mechanisms
DOI 10.1055/s-0036-1593549
Bibliografische Angaben
Nachweis in CareLit
Autor:innenC Bingel, E Koeneke, A Bittmann, M Sill, I Rettig, J Ridinger, U Fernekorn, F Weise, A Schober, O Witt, I Oehme
ZeitschriftKlinische Pädiatrie
Ausgabe11/2016
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
The success rates for investigational cancer drugs in clinical development are poor, reflecting the current limitations of preclinical models in recapitulating relevant (patho-)physiological mechanisms of drug resistance, including autophagy. Recently, three-dimensional (3D) growth cultures have been introduced for preclinical drug testing to improve the lack of correlation between monolayer cell cultures and human…
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Zitierempfehlung
C Bingel, E Koeneke, A Bittmann, M Sill, I Rettig, J Ridinger, U Fernekorn, F Weise, A Schober, O Witt, I Oehme (2016) Three-dimensional tumor cell growth models in vivo drug resistance mechanisms. Klinische Pädiatrie (11). https://doi.org/10.1055/s-0036-1593549
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