CareLit · DOI-Nachweis · Klinische Pädiatrie
High throughput screening of novel histone deacetylase inhibitors for epigenetic therapy of primary brain tumors
DOI 10.1055/s-0036-1593554
Bibliografische Angaben
Nachweis in CareLit
Autor:innenV Marquardt, FK Hansen, J Felsberg, G Reifenberger, A Borkhardt, T Kurz, M Remke
ZeitschriftKlinische Pädiatrie
Ausgabe11/2016
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
The complex interplay between histone deacetylases (HDACs) and histone acetyltransferases (HATs) plays a crucial role in the regulation of gene expression. By removing and adding acetyl groups to histone proteins, the affinity of histones and DNA is tightly regulated. As key players of epigenetic and posttranslational modification, HDACs therefore represent a promising therapeutic target in cancer harboring distinct…
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Zitierempfehlung
V Marquardt, FK Hansen, J Felsberg, G Reifenberger, A Borkhardt, T Kurz, M Remke (2016) High throughput screening of novel histone deacetylase inhibitors for epigenetic therapy of primary brain tumors. Klinische Pädiatrie (11). https://doi.org/10.1055/s-0036-1593554
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