CareLit · DOI-Nachweis · Klinische Pädiatrie
Temporal and mechanistic studies on the resistance of glioma cells to temozolomide
DOI 10.1055/s-0036-1593561
Bibliografische Angaben
Nachweis in CareLit
Autor:innenWP Roos, M Eich, S Quiros, AV Knizhnik, T Nikolova, M Christmann, B Kaina
ZeitschriftKlinische Pädiatrie
Ausgabe11/2016
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
The methylating agent temozolomide is routinely used in the treatment of malignant gliomas. Here we report on the mechanisms glioma cells utilize in protecting themselves against the clinical relevant DNA lesion, O6-methylguanine, induced by temozolomide. Making use of interference RNA, pharmacological inhibition and protein expression approaches we showed that the secondary lesions that form due to the mismatch rep…
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Zitierempfehlung
WP Roos, M Eich, S Quiros, AV Knizhnik, T Nikolova, M Christmann, B Kaina (2016) Temporal and mechanistic studies on the resistance of glioma cells to temozolomide. Klinische Pädiatrie (11). https://doi.org/10.1055/s-0036-1593561
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