CareLit · DOI-Nachweis · Aktuelle Rheumatologie
CD137 mediated T cell costimulation terminates existing autoimmune disease in SLE-prone NZB/NZW F1 mice
DOI 10.1055/s-2003-45034
Bibliografische Angaben
Nachweis in CareLit
Autor:innenJL Foell, B Hewes, M McCausland, S Strahotin, SP O'Neil, M Haber, AS Bapat, PN Chandler, X Yan, N Chioriazzi, MK Hoffmann, RS Mittler
ZeitschriftAktuelle Rheumatologie
Ausgabe11/2003
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
CD137 (4-1BB) is a T cell costimulatory receptor and member of the TNFR superfamily, which is expressed on activated T cells, NK cells and dendritic cells. Its natural ligand, 4-1BB ligand, is constitutively expressed on B cells and on activated antigen presenting cells. We have shown that mAbs against CD137 preferentially costimulate CD8+ T cells, protect them from apoptosis, induce CD8+ CTL mediated killing of est…
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Zitierempfehlung
JL Foell, B Hewes, M McCausland, S Strahotin, SP O'Neil, M Haber, AS Bapat, PN Chandler, X Yan, N Chioriazzi, MK Hoffmann, RS Mittler (2003) CD137 mediated T cell costimulation terminates existing autoimmune disease in SLE-prone NZB/NZW F1 mice. Aktuelle Rheumatologie (11). https://doi.org/10.1055/s-2003-45034
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