CareLit · DOI-Nachweis · Aktuelle Rheumatologie
Expression of RAG1, RAG2 and VpreB genes in IgD+CD5± peripheral B cells during cyclophosphamide treatment in pediatric SLE
DOI 10.1055/s-2003-45081
Bibliografische Angaben
Nachweis in CareLit
Autor:innenH Morbach, SK Singh, U Samfas, C Faber, PE Lipsky, HJ Girschick
ZeitschriftAktuelle Rheumatologie
Ausgabe11/2003
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Peripheral B cells of adult SLE patients express recombination activating genes RAG1/2 and surrogate light chain (VpreB) suggesting secondary receptor revision. In pediatric SLE data on receptor revision is limited. We analyzed the expression of RAG1, RAG2 and VpreB mRNA in peripheral IgD+CD5± B cells of a juvenile SLE patient during cyclophosphamide therapy. Using FACS sorting and single cell RT-PCR, the frequency…
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Zitierempfehlung
H Morbach, SK Singh, U Samfas, C Faber, PE Lipsky, HJ Girschick (2003) Expression of RAG1, RAG2 and VpreB genes in IgD+CD5± peripheral B cells during cyclophosphamide treatment in pediatric SLE. Aktuelle Rheumatologie (11). https://doi.org/10.1055/s-2003-45081
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