CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Halofuginone stimulates interstitial collagenase activity in HSC via activation of p38 and nuclear factor kappa B
DOI 10.1055/s-2004-816037
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Autor:innenY Popov, M Bauer, E Niedobitek, N Patsenker, M Pines, D Schuppan
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe02/2004
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Aims: The semisynthetic plant alkaloid Halofuginone (HAL) was reported to be a specific inhibitor of procollagen I expression and shown to ameliorate thioacetamide-induced rat liver fibrosis. We recently found that the antifibrotic potential of HAL is likely to be associated with a strong MMP induction in activated hepatic stellate cells (HSC). Our present study aimed to investigate molecular mechanisms involved in…
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Zitierempfehlung
Y Popov, M Bauer, E Niedobitek, N Patsenker, M Pines, D Schuppan (2004) Halofuginone stimulates interstitial collagenase activity in HSC via activation of p38 and nuclear factor kappa B. Zeitschrift für Gastroenterologie (02). https://doi.org/10.1055/s-2004-816037
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