CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Beta 3-specific non-peptidic integrin inhibitor EMD409915 blocks PDGF-BB stimulated migration in HSC via inhibition of p38 signalling pathway
DOI 10.1055/s-2004-816040
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Autor:innenE Patsenker, Y Popov, M Wiesner, S Goodman, D Schuppan
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe02/2004
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
Aims: Platelet-derived growth factor (PDGF) is known to be the most potent stimulator of migration and proliferation for activated hepatic stellate cells (HSC) and the expression of PDGF-ß-receptors is increased during liver fibrosis. We aimed to investigate the effect of beta 3-integrin subunit blockade using a specific non-peptidic inhibitor EMD409915 on HSC migration, proliferation, and signal transduction. Mater…
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Zitierempfehlung
E Patsenker, Y Popov, M Wiesner, S Goodman, D Schuppan (2004) Beta 3-specific non-peptidic integrin inhibitor EMD409915 blocks PDGF-BB stimulated migration in HSC via inhibition of p38 signalling pathway. Zeitschrift für Gastroenterologie (02). https://doi.org/10.1055/s-2004-816040
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