CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
The guanine exchange factor Net1 is induced upon TGF-beta stimulation during transdifferentiation of hepatic stellate cells
DOI 10.1055/s-2004-816058
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Autor:innenR Müller, M Kreuzaler, HM Said, AM Gressner, S Dooley
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe02/2004
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Activation of hepatic stellate cells (HSC), the key fibrogenic cell type inside the liver, is mediated by TGF-beta. One hallmark of TGF-beta mediated transdifferentiation is the reorganization of the actin cytoskeleton. Actin reorganization requires activity of RhoA GTPase, which is activated by a Smad-dependent mechanism after stimulation with TGF-beta. Moreover RhoA activity may be related to the amount of Net1 pr…
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Zitierempfehlung
R Müller, M Kreuzaler, HM Said, AM Gressner, S Dooley (2004) The guanine exchange factor Net1 is induced upon TGF-beta stimulation during transdifferentiation of hepatic stellate cells. Zeitschrift für Gastroenterologie (02). https://doi.org/10.1055/s-2004-816058
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