CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
YB-1 mediates IFN-γ dependent regulation of TGF-β responsive genes, thereby providing antifibrotic effects
DOI 10.1055/s-2004-816063
Bibliografische Angaben
Nachweis in CareLit
Autor:innenHM Said, A En-Nia, P Mertens, AM Gressner, S Dooley
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe02/2004
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Hepatic stellate cells (HSC) are the main producers of type I collagen (Col1) in normal and cirrhotic liver. The function of TGF-b as profibrogenic cytokine and inducer of collagen expression has been exploited in TGF-b antagonizing strategies to experimentally reduce collagen content and fibrogenesis. In HSC, Smads3/4 mediate the TGF-b effect to the collagen promoter, which can be abrogated in vitro and in vivo by…
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Zitierempfehlung
HM Said, A En-Nia, P Mertens, AM Gressner, S Dooley (2004) YB-1 mediates IFN-γ dependent regulation of TGF-β responsive genes, thereby providing antifibrotic effects. Zeitschrift für Gastroenterologie (02). https://doi.org/10.1055/s-2004-816063
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