CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Identification of Id1 as target gene of profibrogenic TGF-β family signaling during transdifferentiation of hepatic stellate cells
DOI 10.1055/s-2004-816066
Bibliografische Angaben
Nachweis in CareLit
Autor:innenE Wiercinska, L Wickert, J Hamzavi, AM Gressner, S Dooley
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe02/2004
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Members of the Id subfamily of helix-loop-helix (HLH) proteins are involved in regulation of cellular proliferation and differentiation by inhibiting DNA-binding activity of basic-HLH (bHLH) proteins. In the present study we demonstrate upregulation of Id1 protein expression in hepatic stellate cells (HSC) after stimulation with TGF-β. This cytokine is essential for HSC transdifferentiation and mediates liver fibros…
Zitieren
Zitierempfehlung
E Wiercinska, L Wickert, J Hamzavi, AM Gressner, S Dooley (2004) Identification of Id1 as target gene of profibrogenic TGF-β family signaling during transdifferentiation of hepatic stellate cells. Zeitschrift für Gastroenterologie (02). https://doi.org/10.1055/s-2004-816066
Mit CareLit weiterarbeiten