CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Scavenging endogenous PDGF B-chain by adenovirus-mediated PDGFbetaR-Fc gene transfer potentially inhibits HSC activation and attenuates liver fibrosis
DOI 10.1055/s-2004-816067
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Autor:innenE Borkham-Kamphorst, D Stoll, AM Gressner, R Weiskirchen
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe02/2004
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Platelet-derived growth factor (PDGF), especially its B chain, has been implicated in the pathogenesis of proliferative disorders such as malignancies, atherosclerosis, and fibrotic conditions. We constructed a replication-deficient recombinant adenovirus containing the gene encoding an extracellular domain of rat PDGFbeta receptor (PDGFbetaR) fused with human IgG-Fc. The adenoviral PDGFbetaR-Fc construct was transd…
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Zitierempfehlung
E Borkham-Kamphorst, D Stoll, AM Gressner, R Weiskirchen (2004) Scavenging endogenous PDGF B-chain by adenovirus-mediated PDGFbetaR-Fc gene transfer potentially inhibits HSC activation and attenuates liver fibrosis. Zeitschrift für Gastroenterologie (02). https://doi.org/10.1055/s-2004-816067
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