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Improved Power and Resolution of QTL Mapping for Cholesterol Gallstone Susceptibility Loci Based on Combined Analysis of Two Independent Crosses

H Wittenburg, R Li, MA Lyons, MC Carey, J Mössner, GA Churchill, B Paigen · Zeitschrift für Gastroenterologie · Ausgabe 02/2004

DOI 10.1055/s-2004-816089

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Autor:innenH Wittenburg, R Li, MA Lyons, MC Carey, J Mössner, GA Churchill, B Paigen
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe02/2004
Jahrgang / SeitenNicht angegeben

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Abstract-Vorschau

To date, employing quantitative trait locus (QTL) mapping, we have identified 16 loci that harbor cholesterol gallstone (GS) susceptibility genes (Lith loci) in inbred mice. We previously reported QTL mapping in two separate crosses of gallstone-susceptible PERA/Ei mice with each of the resistant strains I/LnJ and DBA/2J. Here, we re-analyzed the combined data based on a new binary allelic model. After consumption o…

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H Wittenburg, R Li, MA Lyons, MC Carey, J Mössner, GA Churchill, B Paigen (2004) Improved Power and Resolution of QTL Mapping for Cholesterol Gallstone Susceptibility Loci Based on Combined Analysis of Two Independent Crosses. Zeitschrift für Gastroenterologie (02). https://doi.org/10.1055/s-2004-816089

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