CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Cell killing and gene transfer by parvovirus H1 and derived vector in human HCC cells that lack P53
DOI 10.1055/s-2004-816108
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Autor:innenM Möhler, M Zeidler, S Küster, PR Galle, J Rommelaere, J Cornelis
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe02/2004
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Mutations in the tumor suppressor p53 are a common event in human heptocellular carcinoma (HCC). Abrogations of p53 function lead to more aggressive cancer phenotypes and worse clinical outcome. Thus, a major goal of molecular oncology is to identify means to kill cells lacking p53. Autonomous parvoviruses preferentially replicate in and kill transformed cells and reduce the incidence of spontaneous and implanted tu…
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Zitierempfehlung
M Möhler, M Zeidler, S Küster, PR Galle, J Rommelaere, J Cornelis (2004) Cell killing and gene transfer by parvovirus H1 and derived vector in human HCC cells that lack P53. Zeitschrift für Gastroenterologie (02). https://doi.org/10.1055/s-2004-816108
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