CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Smad7 enhances TGF-β dependent apoptosis in hepatocytes
DOI 10.1055/s-2004-816113
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Autor:innenK Biltekin, B Bauche, E Wiercinska, H Said, AM Gressner, S Dooley
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe02/2004
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
One of the major tumorsuppressor functions of TGF-β is negative control of cell growth. Therefore, mutational inactivation or dysregulated expression of components in its signaling pathway have been associated with cancer. We found overexpression of Smad7 in 85% of hepatocellular carcinoma (HCC) samples. Smad7 is an intracellular antagonist of TGF-β and its up-regulation may cause escape from the antiproliferative e…
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Zitierempfehlung
K Biltekin, B Bauche, E Wiercinska, H Said, AM Gressner, S Dooley (2004) Smad7 enhances TGF-β dependent apoptosis in hepatocytes. Zeitschrift für Gastroenterologie (02). https://doi.org/10.1055/s-2004-816113
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