CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Alcohol-related vitamin A hepatotoxicity is mediated by polar retinoid metabolites and involves apoptosis
DOI 10.1055/s-2004-816122
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Autor:innenD Zili, Y Popov, E Patsenker, C Liu, XD Wang, HK Seitz, D Schuppan, F Stickel
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe02/2004
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: Vitamin A hepatotoxicity may be markedly increased by concomitant alcohol consumption but the mechanisms of this interaction are poorly understood. Alcohol-induced hepatic microsomal cytochrome P4502E1 metabolizes retinoids into polar metabolites which may be responsible for the observed liver damage. However, direct experimental evidence supporting this hypothesis is still lacking. Aim: To investigate…
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Zitierempfehlung
D Zili, Y Popov, E Patsenker, C Liu, XD Wang, HK Seitz, D Schuppan, F Stickel (2004) Alcohol-related vitamin A hepatotoxicity is mediated by polar retinoid metabolites and involves apoptosis. Zeitschrift für Gastroenterologie (02). https://doi.org/10.1055/s-2004-816122
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