CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Hepatocellular STAT activation via the receptor gp130 leads to liver protection in T-cell mediated hepatitis– IL6/gp130 signalling in liver protection
DOI 10.1055/s-2004-816158
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Autor:innenC Klein, T Wüstefeld, S Rose-John, MP Manns, C Trautwein
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe02/2004
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
The IL6/gp130 signalling in hepatocytes is protective in ConA hepatitis. To determine the cellular transducers in the IL6/gp130 dependend liver protection we generated mice with hepatocyte specific deletions for gp130 STAT or RAS signalling to differentiate the IL6/gp130 downstream cascades in this model. For the functional characterisation of these new transgenic mice, we isolated primary hepatocytes from ΔSTAT and…
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Zitierempfehlung
C Klein, T Wüstefeld, S Rose-John, MP Manns, C Trautwein (2004) Hepatocellular STAT activation via the receptor gp130 leads to liver protection in T-cell mediated hepatitis– IL6/gp130 signalling in liver protection. Zeitschrift für Gastroenterologie (02). https://doi.org/10.1055/s-2004-816158
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