CareLit · DOI-Nachweis · Klinische Pädiatrie
Lentivirus-mediated osteosarcoma-selective chemogene therapy employing the human folylpolyglutamate synthetase/methotrexate system and the human osteocalcin promoter
DOI 10.1055/s-2004-828552
Bibliografische Angaben
Nachweis in CareLit
Autor:innenK Bienemann, CM Kramm
ZeitschriftKlinische Pädiatrie
Ausgabe05/2004
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
The antifolate methotrexate (MTX) is an important chemotherapeutic agent for treatment of osteosarcomas. This drug usually converts intracellulary into polyglutamate derivates by the enzyme folylpolyglutamate synthetase (FPGS). MTX polyglutamates show an enhanced and prolonged cytotoxicity in comparison to the monoglutamate. We, therefore, investigated in the present study if transfer of the human fpgs gene to osteo…
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Zitierempfehlung
K Bienemann, CM Kramm (2004) Lentivirus-mediated osteosarcoma-selective chemogene therapy employing the human folylpolyglutamate synthetase/methotrexate system and the human osteocalcin promoter. Klinische Pädiatrie (05). https://doi.org/10.1055/s-2004-828552
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