CareLit · DOI-Nachweis · Klinische Pädiatrie
SOX18 is a target gene of the Shh-Ptc pathway in murine cerebellar granule cell precursors and is highly expressed in human desmoplastic medulloblastomas
DOI 10.1055/s-2004-828555
Bibliografische Angaben
Nachweis in CareLit
Autor:innenH Brune, R Buslei, A Koch, W Hartmann, U Schüller, J Kraetzschmar, OD Wiestler, K Schilling, T Pietsch
ZeitschriftKlinische Pädiatrie
Ausgabe05/2004
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Medulloblastomas (MBs) are the most frequent malignant brain tumours in childhood and can be subdivided into the classic and the desmoplastic variant. The latter arises from cerebellar granule cell progenitors (GCPs) of the external granule cell layer (EGL). Its pathogenesis is linked to an overactivation of the Sonic Hedgehog-Patched (Shh-Ptc) pathway. By culturing murine GCPs in the presence or absence of the morp…
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Zitierempfehlung
H Brune, R Buslei, A Koch, W Hartmann, U Schüller, J Kraetzschmar, OD Wiestler, K Schilling, T Pietsch (2004) SOX18 is a target gene of the Shh-Ptc pathway in murine cerebellar granule cell precursors and is highly expressed in human desmoplastic medulloblastomas. Klinische Pädiatrie (05). https://doi.org/10.1055/s-2004-828555
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