CareLit · DOI-Nachweis · Klinische Pädiatrie
The CD70-CD27 pathway is essential for stimulation of a cytotoxic T-cells against acute lymphoblastic leukemia (ALL) cells
DOI 10.1055/s-2004-828566
Bibliografische Angaben
Nachweis in CareLit
Autor:innenL Glouchkova, B Ackermann, D Dilloo
ZeitschriftKlinische Pädiatrie
Ausgabe05/2004
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
In vivo, the T-cell stimulatory capacity of acute lymphoblastic B-cells is poor which has been attributed to low levels of costimulatory surface molecules. CD40-stimulation of B-ALL cells leads to significant upregulation of CD80, CD86 as well as CD70 enhancing allogeneic T-cell-proliferative responses >3fold (n=18). Blockade experiments showed that in the induction of T-cell proliferation CD80/CD86 and CD70 act syn…
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Zitierempfehlung
L Glouchkova, B Ackermann, D Dilloo (2004) The CD70-CD27 pathway is essential for stimulation of a cytotoxic T-cells against acute lymphoblastic leukemia (ALL) cells. Klinische Pädiatrie (05). https://doi.org/10.1055/s-2004-828566
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