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Hepatocyte growth factor and its receptor c-Met are involved in the invasion of TrkB overexpressing human neuroblastoma cells

M Hecht, J Wilting, M Papoutsi, A Eggert, L Schweigerer · Klinische Pädiatrie · Ausgabe 05/2004

DOI 10.1055/s-2004-828572

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Autor:innenM Hecht, J Wilting, M Papoutsi, A Eggert, L Schweigerer
ZeitschriftKlinische Pädiatrie
Ausgabe05/2004
Jahrgang / SeitenNicht angegeben

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Abstract-Vorschau

Neuroblastoma is the most frequent solid malignancy of childhood with advanced stage mortalities of approximately 80%. Neuroblastomas have a heterogenous biological and clinical behaviour. The mechanisms underlying good or poor prognosis are still poorly understood. However, amplification/overexpression of the oncogene N-Myc and the neurotrophin receptor TrkB are known to contribute to a highly malignant phenotype.…

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Zitierempfehlung

M Hecht, J Wilting, M Papoutsi, A Eggert, L Schweigerer (2004) Hepatocyte growth factor and its receptor c-Met are involved in the invasion of TrkB overexpressing human neuroblastoma cells. Klinische Pädiatrie (05). https://doi.org/10.1055/s-2004-828572

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