CareLit · DOI-Nachweis · Klinische Pädiatrie
In depth analysis of aberrantly methylated genes detected by genome scanning in medulloblastoma and other malignancies of the CNS
DOI 10.1055/s-2004-828580
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Nachweis in CareLit
Autor:innenT Lenschen, J Mühlisch, H Jürgens, C Plass, D Smiraglia, MC Frühwald
ZeitschriftKlinische Pädiatrie
Ausgabe05/2004
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: Silencing of genes by methylation is an important mechanism to inactivate tumor suppressor genes. Restriction Landmark Genomic Scanning using restriction enzyme combinations with NotI EcoRV or AscI EcoRV allow the scan of up to 4.000 CpG-Islands for aberrant methylation. Thus genes that might play a role in tumor development and metastasis can be identified. Results: The examination of 3 anaplastic epe…
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Zitierempfehlung
T Lenschen, J Mühlisch, H Jürgens, C Plass, D Smiraglia, MC Frühwald (2004) In depth analysis of aberrantly methylated genes detected by genome scanning in medulloblastoma and other malignancies of the CNS. Klinische Pädiatrie (05). https://doi.org/10.1055/s-2004-828580
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