CareLit · DOI-Nachweis · Klinische Pädiatrie
Down-regulation of PKCη or Bcl-xL, but not Bcl-2, potentiates the cytotoxic effects of TRAIL in prostate cancer cells
DOI 10.1055/s-2004-828588
Bibliografische Angaben
Nachweis in CareLit
Autor:innenA Sagrauske, J Sonnemann, C Müller, JF Beck
ZeitschriftKlinische Pädiatrie
Ausgabe05/2004
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
TRAIL is a promising candidate for the treatment of cancer. However, some tumours display resistance to TRAIL, prompting us to explore whether the apoptotic responsiveness of cancer cells to TRAIL could be enhanced by targeting the novel PKC isoform η, Bcl-2 and Bcl-xL. Transfection of PC-3 cells with second-generation antisense oligonucleotides caused a significant knockdown of the corresponding mRNAs and proteins…
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Zitierempfehlung
A Sagrauske, J Sonnemann, C Müller, JF Beck (2004) Down-regulation of PKCη or Bcl-xL, but not Bcl-2, potentiates the cytotoxic effects of TRAIL in prostate cancer cells. Klinische Pädiatrie (05). https://doi.org/10.1055/s-2004-828588
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