CareLit · DOI-Nachweis · Klinische Pädiatrie
Histone deacetylase Inhibitors have a profound proapoptotic activity in PNET cells
DOI 10.1055/s-2004-828589
Bibliografische Angaben
Nachweis in CareLit
Autor:innenK Saravana Kumar, J Sonnemann, C Müller, JF Beck
ZeitschriftKlinische Pädiatrie
Ausgabe05/2004
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Histone deacetylase inhibitors (HDACIs) are emerging as a new class of antineoplastic agents. Our purpose was to investigate the effects of the HDACIs suberoyl anilide bishydroxamine, trichostatin A, and sodium butyrate against PNET cell lines. Treatment with HDACIs resulted in the time- and dose-dependent accumulation of acetylated histone proteins. Concomitantly, HDACIs provoked the dissipation of the mitochondria…
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Zitierempfehlung
K Saravana Kumar, J Sonnemann, C Müller, JF Beck (2004) Histone deacetylase Inhibitors have a profound proapoptotic activity in PNET cells. Klinische Pädiatrie (05). https://doi.org/10.1055/s-2004-828589
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