CareLit · DOI-Nachweis · Klinische Pädiatrie
Depletion of MLL-AF4 fusion gene by RNAi inhibits proliferation and induces apoptosis in t(4;11)-positive SEM cells
DOI 10.1055/s-2004-828597
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Nachweis in CareLit
Autor:innenM Thomas, C Huenefeld, J Greil, O Heidenreich
ZeitschriftKlinische Pädiatrie
Ausgabe05/2004
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
The t(4;11)(q21;23) translocation is diagnosed in more than 50% of infant high-risk acute lymphoblastic leukemias and is associated with very poor prognosis. Using RNAi, we have silenced the expression of MLL-AF4 fusion gene in the SEM cells carrying t(4;11)(q21;23) translocation. Down-regulation of MLL-AF4 mRNA expression by specific siRNAs caused more than two-fold transient decrease in mRNA levels, reduced 10-fol…
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Zitierempfehlung
M Thomas, C Huenefeld, J Greil, O Heidenreich (2004) Depletion of MLL-AF4 fusion gene by RNAi inhibits proliferation and induces apoptosis in t(4;11)-positive SEM cells. Klinische Pädiatrie (05). https://doi.org/10.1055/s-2004-828597
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