CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Protein transduction domains fused to CAR ectodomain improve adenoviral infection and enhance oncolysis by tumor specific replicating vectors
DOI 10.1055/s-2004-831671
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Nachweis in CareLit
Autor:innenB Schulte, F Kühnel, T Wirth, N Woller, MP Manns, S Kubicka
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe08/2004
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Aims: Downregulation of coxsackievirus-adenovirus-receptor (CAR) expression in tumor cells hampers adenoviral cancer gene therapy as infection efficacy is drastically reduced. We demonstrate that adapter proteins comprising the CAR ectodomain fused to protein transduction domains (PTDs) allow efficient adenoviral infection in nonpermissive tumor cells. Methods/Results: Expression vectors for adapter proteins (CARex-…
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Zitierempfehlung
B Schulte, F Kühnel, T Wirth, N Woller, MP Manns, S Kubicka (2004) Protein transduction domains fused to CAR ectodomain improve adenoviral infection and enhance oncolysis by tumor specific replicating vectors. Zeitschrift für Gastroenterologie (08). https://doi.org/10.1055/s-2004-831671
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