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Peripheral benzodiazepine receptor ligands induce apoptosis and cell cycle arrest in human hepatocellular carcinoma cells and enhance chemosensitivity to paclitaxel, docetaxel, doxorubicin and the Bcl–2 inhibitor HA14–1

A Sutter, K Maaser, P Grabowski, M Höpfner, A Krahn, B Heine, H Stein, R Somasundaram, D Schuppan, M Zeitz, H Scherübl · Zeitschrift für Gastroenterologie · Ausgabe 08/2004

DOI 10.1055/s-2004-831695

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Autor:innenA Sutter, K Maaser, P Grabowski, M Höpfner, A Krahn, B Heine, H Stein, R Somasundaram, D Schuppan, M Zeitz, H Scherübl
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe08/2004
Jahrgang / SeitenNicht angegeben

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Abstract-Vorschau

Background/Aims: Hepatocellular carcinoma (HCC) is one of the most common causes of cancer deaths worldwide. Thus, novel therapies are urgently needed. A promising approach is the use of peripheral benzodiazepine receptor (PBR) ligands which have been shown to inhibit the proliferation of various tumors. There exist no functional studies of PBR in HCC Methods: PBR expression both in human HCC cell lines and in tumor…

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A Sutter, K Maaser, P Grabowski, M Höpfner, A Krahn, B Heine, H Stein, R Somasundaram, D Schuppan, M Zeitz, H Scherübl (2004) Peripheral benzodiazepine receptor ligands induce apoptosis and cell cycle arrest in human hepatocellular carcinoma cells and enhance chemosensitivity to paclitaxel, docetaxel, doxorubicin and the Bcl–2 inhibitor HA14–1. Zeitschrift für Gastroenterologie (08). https://doi.org/10.1055/s-2004-831695

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