CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Hepatocellular IL6/gp130/STAT signalling protects the liver in T-cell mediated hepatitis by a massive up-regulation of SAA protein
DOI 10.1055/s-2004-831746
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Autor:innenC Klein, T Wüstefeld, S Rose-John, MP Manns, C Trautwein
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe08/2004
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
To determine the molecular transducers of the IL6/gp130 dependend liver protection in the ConA hepatitis, we generated mice with hepatocyte specific deletions for gp130 STAT or RAS signalling to differentiate the gp130 downstream cascades in this model and to identify potential effecter molecules.To verify the phenotype of the new mice strains on functional level, we isolated primary hepatocytes from ΔSTAT and ΔRAS…
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Zitierempfehlung
C Klein, T Wüstefeld, S Rose-John, MP Manns, C Trautwein (2004) Hepatocellular IL6/gp130/STAT signalling protects the liver in T-cell mediated hepatitis by a massive up-regulation of SAA protein. Zeitschrift für Gastroenterologie (08). https://doi.org/10.1055/s-2004-831746
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